MiRNA-494 induces trophoblast senescence by targeting SIRT1

Objective Although the mechanism underlying preeclampsia (PE) has been widely explored, the mechanisms related to senescence have not yet been fully revealed. Therefore, we investigated the role of the miR-494/longevity protein Sirtuin 1 (SIRT1) axis in PE.Methods Human placental tissue was obtained from severe preeclampsia (SPE) (n?=?20) and gestational age-matched normotensive pregnancies (n?=?20), and senescence-associated β-galactosidase (SAβG) and SIRT1 expression levels were measured. The TargetScan and miRDB databases predicted candidate miRNAs targeting SIRT1, and intersected with differentially expressed miRNAs in the GSE15789 dataset (p?

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