F3104502

Anti-Rat CD45 (OX1)，PE 流式抗体 (新品)

¥792.00 – ¥1,760.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

分子靶点：CD45, GP180, PTPRC
种属：大鼠 (Rat)
标记：PE
亚型：Mouse IgG1, κ
克隆号：OX1

在售SKU, 70-AR04504-20, 70-AR04504-50, 70-AR04504-100, AR04504, 70-F3104502-25, 70-F3104502-100

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Size
库存号

文章目录[隐藏]

分子信息
PTPRC 分子靶点信息概述
PTPRC 分子靶点综述
- 大鼠 Rat Ptprc 分子靶点信息
- 大鼠 Rat Ptprc 靶点分子功能（预测）

商品名	Anti-Rat CD45 (OX1)，PE 流式抗体
靶点	CD45, GP180, PTPRC
标记	PE
仪器	适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	OX1
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

分子信息

概述大鼠 CD45, GP180, PTPRC 靶点信息

PTPRC 分子靶点信息概述

分子名：PTPRC, protein tyrosine phosphatase receptor type C
基因家族：CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type
别名：LCA; T200; GP180
曾用名：CD45

PTPRC 分子靶点综述

CD45也被称为白细胞共同抗原(leukocyte common antigen, LCA)，由一类结构相似，分子量较大(180 kDa、190 kDa、205 kDa和200 kDa)的跨膜蛋白组成，广泛存在于所有白细胞表面(包括淋巴细胞、粒细胞和单核细胞)，但不表达于成熟的红细胞、血小板、骨髓中的成熟红系细胞以及非造血组织。CD45胞浆区段具有蛋白质酪氨酸磷酸酶的作用，能使底物P56lck和P59fyn上酪氨酸脱磷酸而激活，在细胞的信息传导中发挥重要作用，CD45是细胞膜上信号传导的关键分子，在淋巴细胞的发育成熟，功能调节及信号传递中具有重要意义。CD45的分布可作为某些T细胞亚群的分类标志。

大鼠 Rat Ptprc 分子靶点信息

分子名：Ptprc, protein tyrosine phosphatase, receptor type, C
别称：
- CD45
- L-CA
- Lca
- leucocyte common antigen
- leukocyte common antigen
- leukocyte common antigen A
- leukocyte common antigen B
- Protein tyrosine phosphatase, receptor-type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- RT7
- T200
- T200 glycoprotein
基因序列：NCBI_Gene: 24699
蛋白序列：UniProtKB: P04157

大鼠 Rat Ptprc 靶点分子功能（预测）

Enables protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).