F3108002

Anti-Rat CD80 (B7-1), PE (Clone:3H5)流式抗体 (新品)

¥1,000.00 – ¥2,200.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

分子靶点：CD80, B7-1
种属：大鼠 (Rat)
标记：PE
亚型：Mouse IgG1, κ
克隆号：3H5

在售SKU, 70-AR08004-20, 70-AR08004-50, 70-AR08004-100, AR08004, 70-F3108002-25, 70-F3108002-100

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库存号

文章目录[隐藏]

分子信息
CD80 分子靶点信息概述
CD80 分子靶点综述
- 大鼠 Rat Cd80 分子靶点信息
- 大鼠 Rat Cd80 靶点分子功能（预测）

商品名	Anti-Rat CD80 (B7-1), PE (Clone:3H5)流式抗体
靶点	CD80, B7-1
标记	PE
仪器	适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	3H5
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

图 - 图.SD 大鼠脾细胞经 LPS 刺激 3 天后染色 Anti-Rat CD80, PE (AR08004)和Anti-Rat CD8α, APC (AR008A0205)的结果。已排除黏连细胞。

分子信息

概述大鼠 CD80, B7-1 靶点信息

CD80 分子靶点信息概述

分子名：CD80, CD80 molecule
基因家族：CD molecules; V-set domain containing; C2-set domain containing; B7 family
别名：B7.1; B7-1
曾用名：CD28LG; CD28LG1
全称：B-lymphocyte activation antigen B7; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule

CD80 分子靶点综述

抗原分化簇80(CD80)是在树突状细胞、活化的B细胞和单核细胞上发现的蛋白，其为T细胞活化和存活提供必要的共刺激信号。它也被称为B7-1。B7-1的cDNA预测为I型膜蛋白，即在内质膜上易位的信号肽上合成的一种膜蛋白。预测蛋白质含有2个胞外结构域，其结构与Ig、疏水跨膜区域和短胞质结构域相似。CD80和CD86基因分别编码B7-1和B7-2，它们是在各种造血细胞类型上表达的免疫球蛋白超家族的结构相似的成员。B7-1和B7-2通过与CD28和CTLA4相互作用，向T细胞提供共刺激信号。

大鼠 Rat Cd80 分子靶点信息

分子名：Cd80, Cd80 molecule
别称：
- B7-1
- Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)
- CD80 antigen
- CD80-like
- LOC100360171
- T-lymphocyte activation antigen CD80
基因序列：NCBI_Gene: 25408
蛋白序列：

大鼠 Rat Cd80 靶点分子功能（预测）

Predicted to enable coreceptor activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).