EK1182

Human ErbB2/HER2/CD340 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1182-48, 70-EK1182-96, EK1182

分子靶点：ERBB2
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本10μL
灵敏度：0.51pg/mL
检测范围：31.25-2000pg/mL
回收率：85%-112%

¥<\/span>1,600.00<\/bdi><\/span><\/span>","sku":"70-EK1182-48","variation_description":"","variation_id":8292,"variation_is_active":true,"variation_is_visible":true,"weight":"","weight_html":"N\/A"},{"attributes":{"attribute_size":"96T"},"availability_html":"","backorders_allowed":false,"dimensions":{"length":"","width":"","height":""},"dimensions_html":"N\/A","display_price":2650,"display_regular_price":2650,"image":{"title":"ELISA-1.jpg","caption":"","url":"https:\/\/ecdn.liankebio.cn\/wp-content\/uploads\/ELISA-1.jpg","alt":"","src":"https:\/\/ecdn.liankebio.cn\/wp-content\/uploads\/ELISA-1.jpg","srcset":"https:\/\/www.liankebio.com\/wp-content\/uploads\/ELISA-1.jpg 800w, https:\/\/www.liankebio.com\/wp-content\/uploads\/ELISA-1-768x576.jpg 768w","sizes":"(max-width: 800px) 100vw, 800px","full_src":"https:\/\/ecdn.liankebio.cn\/wp-content\/uploads\/ELISA-1.jpg","full_src_w":800,"full_src_h":600,"gallery_thumbnail_src":"https:\/\/ecdn.liankebio.cn\/wp-content\/uploads\/ELISA-1-100x100.jpg","gallery_thumbnail_src_w":100,"gallery_thumbnail_src_h":100,"thumb_src":"https:\/\/ecdn.liankebio.cn\/wp-content\/uploads\/ELISA-1.jpg","thumb_src_w":800,"thumb_src_h":600,"src_w":800,"src_h":600},"image_id":5986,"is_downloadable":false,"is_in_stock":true,"is_purchasable":true,"is_sold_individually":"no","is_virtual":false,"max_qty":"","min_qty":1,"price_html":"¥<\/span>2,650.00<\/bdi><\/span><\/span>","sku":"70-EK1182-96","variation_description":"","variation_id":8293,"variation_is_active":true,"variation_is_visible":true,"weight":"","weight_html":"N\/A"}]">

Size
库存号

ELISA试剂盒详细信息

商品名	Human ErbB2/HER2/CD340 ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	ERBB2
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本10μL
灵敏度	0.51pg/mL
线性范围	31.25-2000pg/mL
精密度	板内变异系数：1.9%-3.2%;板间变异系数：2.1%-3.7%
回收率	85%-112%
平均回收率	106%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人ErbB2抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、检测样本和辣根过氧化物酶标记的检测抗体，经过孵育，样本中存在的ErbB2与固相抗体和检测抗体结合。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中ErbB2的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
ERBB2 分子靶点信息概述
ERBB2 分子靶点综述
- 人 Human ERBB2 分子靶点信息
- 人 Human ERBB2靶点分子功能（预测）

分子信息

概述人 ERBB2, HER2, CD340, NEU 靶点信息

ERBB2 分子靶点信息概述

分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
基因家族：CD molecules; Minor histocompatibility antigens; Erb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
别名：NEU; HER-2; CD340; HER2
曾用名：NGL
全称：neuro/glioblastoma derived oncogene homolog; human epidermal growth factor receptor 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

ERBB2 分子靶点综述

ErbB2在人类中由ERBB2基因编码，通常也称之为原癌基因人类表皮生长因子受体2(HER2)或CD340。HER2由胞外配体结合域、跨膜结构域和胞内结构域3部分组成，这些结构域可以和大量信号分子相互作用，体现出配体依赖和非配体依赖性活性。扩增或过表达该致癌基因对某些不良类型的乳腺癌发展有重要作用。近几年来，该蛋白已成为近30%乳腺癌患者生物治疗的一个重要靶点。

人 Human ERBB2 分子靶点信息

分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
别称：
- c-erb B2/neu protein
- CD340
- HER-2
- HER-2/neu
- HER2
- herstatin
- human epidermal growth factor receptor 2
- metastatic lymph node gene 19 protein
- MLN 19
- NEU
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- NGL
- p185erbB2
- proto-oncogene c-ErbB-2
- proto-oncogene Neu
- receptor tyrosine-protein kinase erbB-2
- TKR1
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- VSCN2
基因序列：NCBI_Gene: 2064
蛋白序列：UniProtKB: P04626

人 Human ERBB2靶点分子功能（预测）

Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; protein phosphorylation; and regulation of MAPK cascade. Acts upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; cytosol; and endosome membrane. Part of ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).