EK1190

Human LDL Receptor/LDLR ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1190-48, 70-EK1190-96, EK1190

分子靶点：LDLR
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本10μL
灵敏度：6.32pg/mL
检测范围：125-8000pg/mL
回收率：101%-112%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human LDL Receptor/LDLR ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	LDLR
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本10μL
灵敏度	6.32pg/mL
线性范围	125-8000pg/mL
精密度	板内变异系数：3%-4.3%;板间变异系数：2.3%-3.6%
回收率	101%-112%
平均回收率	107%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人LDLR抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、检测样本和辣根过氧化物酶标记的检测抗体，经过孵育，样本中存在的LDLR与固相抗体和检测抗体结合。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中LDLR的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
LDLR 分子靶点信息概述
LDLR 分子靶点综述
- 人 Human LDLR 分子靶点信息
- 人 Human LDLR靶点分子功能（预测）

分子信息

概述人 LDLR, LDLCQ2 靶点信息

LDLR 分子靶点信息概述

分子名：LDLR, low density lipoprotein receptor
基因家族：Low density lipoprotein receptors; MicroRNA protein coding host genes
别名：LDLCQ2
全称：familial hypercholesterolemia

LDLR 分子靶点综述

低密度脂蛋白(LDL)受体(LDLR)是一个由839个氨基酸组成的嵌合蛋白，属于LDLR基因家族。它是一种细胞表面受体，可识别嵌入在LDL颗粒外磷脂层上的ApoB100，还可识别存在于乳糜微粒残余物和VLDL残余物中的ApoE蛋白。LDLR介导富含胆固醇的LDL的内吞作用。LDLR复合物存在于细胞表面的网格蛋白包被小窝(或芽)，后者通过衔接蛋白结合LDL-胆固醇，去组装形成网格蛋白包被的内体囊泡，这使LDL-胆固醇在内吞作用过程中发生内在化，还可防止LDL扩散在膜表面。上述过程发生在所有有核细胞中，但是主要发生在肝脏中，通过循环可去除约70%的LDL。上调LDLR导致血脂下降，这可能与甲状腺机能亢进有关，而甲状腺机能减退却相反。

人 Human LDLR 分子靶点信息

分子名：LDLR, low density lipoprotein receptor
别称：
- FH
- FHC
- FHCL1
- LDL receptor
- LDLCQ2
- low-density lipoprotein receptor
- low-density lipoprotein receptor class A domain-containing protein 3
基因序列：NCBI_Gene: 3949
蛋白序列：UniProtKB: P01130

人 Human LDLR靶点分子功能（预测）

Enables several functions, including low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and very-low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; cholesterol transport; and long-term memory. Located in several cellular components, including clathrin-coated pit; endosome; and external side of plasma membrane. Part of PCSK9-LDLR complex and receptor complex. Implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Biomarker of systemic lupus erythematosus.