EK1144

Human M-CSF ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1144-48, 70-EK1144-96, EK1144

分子靶点：CSF1
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本20μL
灵敏度：0.19pg/mL
检测范围：31.25-2000pg/mL
回收率：81%-116%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human M-CSF ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	CSF1
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本20μL
灵敏度	0.19pg/mL
线性范围	31.25-2000pg/mL
精密度	板内变异系数：2.1%-4.1%;板间变异系数：3.1%-4%
回收率	81%-116%
平均回收率	102%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人M-CSF抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的M-CSF与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中M-CSF的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
CSF1 分子靶点信息概述
CSF1 分子靶点综述
- 人 Human CSF1 分子靶点信息
- 人 Human CSF1靶点分子功能（预测）

分子信息

概述人 CSF1, MCSF 靶点信息

CSF1 分子靶点信息概述

分子名：CSF1, colony stimulating factor 1
别名：M-CSF; MCSF; MGC31930
全称：macrophage colony stimulating factor 1; colony stimulating factor 1 (macrophage)

CSF1 分子靶点综述

巨噬细胞集落刺激因子(M-CSF)也称为集落刺激因子1(CSF1)是由成骨细胞分泌的细胞因子。它是造血生长因子，参与单核细胞、巨噬细胞和骨髓祖细胞的增殖、分化和存活。血管壁局部产生的M-CSF会促使动脉粥样硬化的进程。M-CSF在肾病中发挥了作用，包括急性肾损伤(AKI)和慢性肾功能衰竭(CRF)。单核细胞的慢性活化会导致CRF患者多种代谢、血液和免疫异常。在AKI患者中，M-CSF可促进修复，但也有相反的作用，促使促炎性巨噬细胞增殖。

人 Human CSF1 分子靶点信息

分子名：CSF1, colony stimulating factor 1
别称：
- colony stimulating factor 1 (macrophage)
- CSF-1
- lanimostim
- macrophage colony stimulating factor
- macrophage colony stimulating factor 1
- macrophage colony-stimulating factor 1
- MCSF
- MGC31930
基因序列：NCBI_Gene: 1435
蛋白序列：UniProtKB: P09603

人 Human CSF1靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of macrophage migration. Acts upstream of or within positive regulation of cell population proliferation. Located in several cellular components, including extracellular space; nuclear body; and perinuclear region of cytoplasm. Implicated in interstitial cystitis. Biomarker of several diseases, including COVID-19; atherosclerosis; end stage renal disease; glomerulonephritis (multiple); and vesicoureteral reflux.