EK1360

Human MICA ELISA Kit检测试剂盒（酶联免疫吸附法）

Name: Human MICA ELISA Kit检测试剂盒（酶联免疫吸附法）
SKU: EK1360
Availability: InStock

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

在售SKU:70-EK1360-48, 70-EK1360-96, EK1360

分子靶点：MICA
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：100μL
灵敏度：2.57pg/mL
检测范围：62.5-4000pg/mL
回收率：80%-120%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human MICA ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	MICA
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	100μL
灵敏度	2.57pg/mL
线性范围	62.5-4000pg/mL
精密度	板内变异系数：4.6%-8.4%;板间变异系数：4.8%-9.3%
回收率	80%-120%
平均回收率	96%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人MICA抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的MICA与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中MICA的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

MICA 分子靶点信息概述
MICA 分子靶点综述
MICA, MHC class I polypeptide-related sequence A 分子靶点种属信息
- 人 Human MICA 分子靶点信息
- 人 Human MICB靶点分子功能（预测）

MICA 分子靶点信息概述

分子名：MICA, MHC class I polypeptide-related sequence A
基因家族：C1-set domain containing
别名：PERB11.1

MICA 分子靶点综述

MHC I 类多肽相关序列 A 是一种在人类中由 MICA 基因编码的蛋白质。MICA 在正常细胞上表达最少，但常在上皮肿瘤上表达或脱落，可被细菌和病毒感染诱导。近年来针对以 MICA 为代表的 NKG2D 受体激活通路及其两者之间的相互调节机制在肿瘤免疫、自身免疫和抗感染免疫等研究领域得到了广泛关注。这种膜蛋白分子能与 NK 细胞表面上的NKG2D 受体结合，从而激活 NK 细胞的杀伤活性。MICA 的识别涉及到肿瘤监测、病毒感染和自身免疫疾病。 MICA基因的分布特征与地域、人群等因素有关，不同人群之间等位基因分布频率存在差异。

MICA, MHC class I polypeptide-related sequence A 分子靶点种属信息

人 Human

人 Human MICA 分子靶点信息

分子名：MICA, MHC class I polypeptide-related sequence A
别称：
- FLJ36918
- FLJ60820
- HLA class I antigen
- major histocompatibility complex class I chain-related protein A
- MGC111087
- MGC21250
- MHC class I chain-related gene A protein
- MHC class I chain-related protein A
- MHC class I related chain A
- MHC class I related sequence A
- MIC-A
- PERB11.1
- Stress inducible class I homolog
- truncated MHC class I polypeptide-related sequence A
- truncated MICA
基因序列：NCBI_Gene: 100507436
蛋白序列：UniProtKB: Q29983

人 Human MICB靶点分子功能（预测）

Enables natural killer cell lectin-like receptor binding activity. Involved in several processes, including T cell mediated cytotoxicity; defense response to other organism; and negative regulation of natural killer cell mediated cytotoxicity. Located in cell surface and extracellular space. Is integral component of plasma membrane.