EK1248

Human TrKA/NTRK1 ELISA Kit 检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1248-48, 70-EK1248-96, EK1248

分子靶点：NTRK1
种属：人
样本类型：血清，血浆，细胞上清
检测样本体积：血清、血浆样本10μL
灵敏度：20.02pg/mL
检测范围：0.16-10ng/mL
回收率：80%-108%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human TrKA/NTRK1 ELISA Kit 检测试剂盒（酶联免疫吸附法）
种属	人
靶点	NTRK1
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞上清
检测样本体积	血清、血浆样本10μL
灵敏度	20.02pg/mL
线性范围	0.16-10ng/mL
精密度	板内变异系数：5.4%-7.7%;板间变异系数：6.5%-8.8%
回收率	80%-108%
平均回收率	95%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本，经过孵育，样本中存在的待测物质与捕获抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的检测抗体孵育。洗涤后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长（参考波长 570 - 630nm）测定吸光度值。

分子信息

概述人 Human NTRK1 分子靶点信息

NTRK1 分子靶点信息概述

分子名：NTRK1, neurotrophic receptor tyrosine kinase 1
基因家族：Receptor tyrosine kinases; Immunoglobulin like domain containing
别名：TRK; TRKA; MTC
曾用名：neurotrophic tyrosine kinase, receptor, type 1
全称：high affinity nerve growth factor receptor; tropomyosin receptor kinase A

NTRK1 分子靶点综述

TrkA（Tyrosine kinase receptor ，酪氨酸激酶受体A）是原癌基因Trk的产物，是神经营养酪氨酸激酶受体家族的成员，也被称为高亲和力神经生长因子受体1（NTRK1）。TrkA、TrkB和TrkC分别优先结合NGF、NT-4和BDNF、NT-3。所有Trk家族蛋白都有一个保守的复杂亚结构域组织，包括一个信号肽，两个富含半胱氨酸的结构域，三个富含亮氨酸的基序，细胞外区域的两个类似免疫球蛋白的结构域，以及一个包含酪氨酸激酶结构域的细胞内区域。两种不同的TrkA异构体因其胞外结构域的6个氨基酸插入而不同。较长的TrkA亚型是唯一在神经元组织中表达的亚型，而较短的TrkA主要在非神经元组织中表达。NGF以低亲和力与TrkA结合并激活其细胞质激酶，启动一个介导神经元存活和分化的信号级联。NGF的高亲和力结合需要TrkA与肿瘤坏死因子受体超家族成员之一的p75 NGF受体 (NGFR) 共表达。NGFR以低亲和力结合所有神经营养因子，调节Trk活性，并改变Trk受体对其配体的特异性。

人 Human NTRK1 分子靶点信息

分子名：NTRK1, neurotrophic receptor tyrosine kinase 1
别称：
- DKFZp781I14186
- gp140trk
- high affinity nerve growth factor receptor
- MTC
- neurotrophic tyrosine kinase, receptor, type 1
- Oncogene TRK
- p140-TrkA
- TRK
- trk precursor
- Trk-A
- TRK1
- TRK1-transforming tyrosine kinase protein
- TRKA
- tropomyosin receptor kinase A
- tropomyosin-related kinase A
- tyrosine kinase receptor A
基因序列：NCBI_Gene: 4914
蛋白序列：UniProtKB: P04629

人 Human NTRK1靶点分子功能（预测）

Enables several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including neurotrophin signaling pathway; positive regulation of intracellular signal transduction; and protein phosphorylation. Acts upstream of or within neuron projection development and peptidyl-tyrosine autophosphorylation. Located in plasma membrane. Part of receptor complex. Implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Biomarker of several diseases, including Hirschsprung's disease; lung disease (multiple); neuroblastoma; obstructive sleep apnea; and rhinitis.