EK221

Mouse IL-21 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK221/2-48, 70-EK221/2-96, EK221

分子靶点：IL21
种属：小鼠
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本10μL
灵敏度：0.58pg/mL
检测范围：31.25-2000pg/mL
回收率：85%-114%

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Size
库存号

ELISA试剂盒详细信息

商品名	Mouse IL-21 ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	小鼠
靶点	IL21
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本10μL
灵敏度	0.58pg/mL
线性范围	31.25-2000pg/mL
精密度	板内变异系数：3.0%-5.5%;板间变异系数：3.5%-6.1%
回收率	85%-114%
平均回收率	96%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠IL-21抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-21与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-21的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
IL21 分子靶点信息概述
IL21 分子靶点综述
- 小鼠 Mouse Il21 分子靶点信息
- 小鼠 Mouse Il21 靶点分子功能（预测）

分子信息

概述小鼠 IL21, IL-21 靶点信息

IL21 分子靶点信息概述

分子名：IL21, interleukin 21
基因家族：Interleukins
别名：Za11; IL-21

IL21 分子靶点综述

白细胞介素21(IL-21)对免疫细胞具有强烈的调节作用，包括可破坏病毒感染或肿瘤细胞的自然杀伤细胞(NK)和细胞毒性T细胞。该细胞因子可诱导靶细胞分裂/增殖。IL-21表达于人活化的CD4+T细胞，但在其他大多数组织中并没有表达。此外，IL-21在辅助性T细胞亚群Th2和Th17细胞以及滤泡性T细胞中表达上调。而且IL-21还表达于调控这些细胞功能的NKT细胞中。IL-21在免疫炎性疾病中具有病理作用。研究表明存在一个正向自分泌环，可放大并稳定IL-21驱使的、T细胞介导的应答。而且，它还具有抗肿瘤活性，对自身免疫进程具有作用。在临床上，IL-21还可作为潜在的抗肿瘤药物。

小鼠 Mouse Il21 分子靶点信息

分子名：Il21, interleukin 21
别称：
- 无
基因序列：NCBI_Gene: 60505
蛋白序列：

小鼠 Mouse Il21 靶点分子功能（预测）

Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).