EK317

Rat IL-17A ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK317/3-48, 70-EK317/3-96, EK317

分子靶点：IL17A
种属：大鼠
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：10μL
灵敏度：0.62pg/mL
检测范围：3.13-200pg/mL
回收率：94%-119%

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Size
库存号

ELISA试剂盒详细信息

商品名	Rat IL-17A ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	大鼠
靶点	IL17A
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	10μL
灵敏度	0.62pg/mL
线性范围	3.13-200pg/mL
精密度	板内变异系数：3.9%-7.1%;板间变异系数：3.0%-3.9%
回收率	94%-119%
平均回收率	103%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗大鼠IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-17A与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
IL17A 分子靶点信息概述
IL17A 分子靶点综述
- 大鼠 Rat Il17a 分子靶点信息
- 大鼠 Rat Il17a 靶点分子功能（预测）

分子信息

概述大鼠 IL17A, IL17, CTLA8 靶点信息

IL17A 分子靶点信息概述

分子名：IL17A, interleukin 17A
基因家族：Interleukins
别名：IL-17A; IL-17
曾用名：CTLA8; IL17
全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。

大鼠 Rat Il17a 分子靶点信息

分子名：Il17a, interleukin 17A
别称：
- CTLA-8
- cytotoxic T-lymphocyte-associated antigen 8
- hypothetical protein LOC301289
- IL-17
- IL-17A
- Il17
- interleukin 17
- Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17A
- LOC301289
- similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
基因序列：NCBI_Gene: 301289
蛋白序列：
- UniprotKB: G3V7M4
- UniprotKB: Q61453

大鼠 Rat Il17a 靶点分子功能（预测）

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).