EK1204

Human Apolipoprotein A1/Apo A1 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1204-48, 70-EK1204-96, EK1204

分子靶点：APOA1
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本5μL
灵敏度：0.309ng/mL
检测范围：0.63-40ng/mL
回收率：90%-110%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human Apolipoprotein A1/Apo A1 ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	APOA1
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本5μL
灵敏度	0.309ng/mL
线性范围	0.63-40ng/mL
精密度	板内变异系数：3.4%-6.9%;板间变异系数：2%-7.1%
回收率	90%-110%
平均回收率	101%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人ApoA1抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的ApoA1与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中ApoA1的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
APOA1 分子靶点信息概述
APOA1 分子靶点综述
- 人 Human APOA1 分子靶点信息
- 人 Human APOA1靶点分子功能（预测）

分子信息

概述人 APOA1, apolipoprotein A1 靶点信息

APOA1 分子靶点信息概述

分子名：APOA1, apolipoprotein A1
基因家族：Apolipoproteins
全称：apolipoprotein A-I

APOA1 分子靶点综述

载脂蛋白A1 (Apo A1)是血浆中高密度脂蛋白(HDL)的主要蛋白成分。小肠上皮细胞分泌的乳糜微粒也包含Apo A1，但是它很快就转移到血液的HDL中。该蛋白在脂质代谢中有特定作用，它促进脂肪流出，包括将组织中的胆固醇转运至肝脏完成排泄。它是卵磷脂胆固醇脂酰转移酶的辅因子，负责大部分血浆胆固醇酯的形成。Apo A1也是前列环素的稳定因子，因此可能有抗凝血功能。Apo A1通常作为预测心血管疾病的生物标志物。相比于其它脂质测定，Apo B-100/Apo A1比率已被报道是一种预测心肌梗死风险的有效预测工具。编码Apo A1基因的缺失与HDL缺陷，包括丹吉尔疾病，以及系统性非神经性淀粉样变性有关。

人 Human APOA1 分子靶点信息

分子名：APOA1, apolipoprotein A1
别称：
- apo-AI
- apo(a)
- apoA-I
- apolipoprotein A-I
- HPALP2
- MGC117399
基因序列：NCBI_Gene: 335
蛋白序列：UniProtKB: P02647

人 Human APOA1靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Acts upstream of or within cholesterol transport. Located in endocytic vesicle and extracellular space. Part of spherical high-density lipoprotein particle and very-low-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; liver disease (multiple); and neurodegenerative disease (multiple).