EK1306

Human Cathepsin D ELISA Kit检测试剂盒（酶联免疫吸附法）

Name: Human Cathepsin D ELISA Kit检测试剂盒（酶联免疫吸附法）
SKU: EK1306
Availability: InStock

¥2,000.00 – ¥3,400.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

在售SKU:70-EK1306-48, 70-EK1306-96, EK1306

分子靶点：CTSD
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本5μL
灵敏度：5.52pg/mL
检测范围：39.06-2500pg/mL
回收率：90%-109%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human Cathepsin D ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	CTSD
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本5μL
灵敏度	5.52pg/mL
线性范围	39.06-2500pg/mL
精密度	板内变异系数：2.5%-3.9%;板间变异系数：2.8%-4.3%
回收率	90%-109%
平均回收率	102%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的待测物质与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
CTSD 分子靶点信息概述
CTSD 分子靶点综述
- 人 Human CTSD 分子靶点信息
- 人 Human CTSD靶点分子功能（预测）

分子信息

概述人 CTSD, cathepsin D 靶点信息

CTSD 分子靶点信息概述

分子名：CTSD, cathepsin D
基因家族：Cathepsins; Peptidase family A1
别名：CLN10
曾用名：CPSD
全称：ceroid-lipofuscinosis, neuronal 10; cathepsin D (lysosomal aspartyl protease)

CTSD 分子靶点综述

组织蛋白酶D是由CTSD基因编码的蛋白质。组织蛋白酶D是一种溶酶体天冬氨酰蛋白酶，在低pH下会被激活。它广泛存在于脊椎动物、真菌、反转录病毒和一些植物病毒中。通常情况下，组织蛋白酶D首先在糙面内质网中合成没有催化活性的前体酶原，去除信号肽后进入高尔基体进行蛋白的切割和加工，最终通过甘露糖-6-磷酸途径进入溶酶体中。在哺乳动物中，具有活性的成熟蛋白形式含有l条轻链和1条重链。组织蛋白酶D广泛表达，并参与蛋白水解降解，细胞侵袭和细胞凋亡。组织蛋白酶D基因的突变与几种疾病的发病机理有关，包括乳腺癌和可能的阿尔茨海默氏病在内的多种疾病，并且已被认为是乳腺癌的肿瘤标志物。

人 Human CTSD 分子靶点信息

分子名：CTSD, cathepsin D
别称：
- cathepsin d (lysosomal aspartyl protease)
- ceroid-lipofuscinosis, neuronal 10
- CLN10
- CPSD
- epididymis secretory sperm binding protein Li 130P
- HEL-S-130P
- lysosomal aspartyl peptidase
- lysosomal aspartyl protease
- MGC2311
基因序列：NCBI_Gene: 1509
蛋白序列：UniProtKB: P07339

人 Human CTSD靶点分子功能（预测）

Enables peptidase activity. Involved in several processes, including lipoprotein catabolic process; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in endosome membrane; lysosomal membrane; and membrane raft. Colocalizes with collagen-containing extracellular matrix. Implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Biomarker of Alzheimer's disease.