EK1219

Human CXCL5/ENA-78 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

说明书

在售SKU:70-EK1219-48, 70-EK1219-96, EK1219

分子靶点：CXCL5
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本10μL
灵敏度：13.45pg/mL
检测范围：31.25-2000pg/mL
回收率：82%-125%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human CXCL5/ENA-78 ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	CXCL5
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本10μL
灵敏度	13.45pg/mL
线性范围	31.25-2000pg/mL
精密度	板内变异系数：4.9%-6.4%;板间变异系数：2.8%-3.9%
回收率	82%-125%
平均回收率	101%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人CXCL5抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的CXCL5与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中CXCL5的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
CXCL5 分子靶点信息概述
CXCL5 分子靶点综述
- 人 Human CXCL5 分子靶点信息
- 人 Human CXCL5靶点分子功能（预测）

分子信息

概述人 CXCL5, ENA-78 靶点信息

CXCL5 分子靶点信息概述

分子名：CXCL5, C-X-C motif chemokine ligand 5
基因家族：Chemokine ligands
别名：ENA-78
曾用名：SCYB5
全称：small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); chemokine (C-X-C motif) ligand 5

CXCL5 分子靶点综述

C-X-C基序趋化因子5(CXCL5)，又名上皮来源的中性粒细胞激活肽78(ENA-78)，是CXC趋化因子家族中的小分子量细胞因子。炎性细胞因子IL-1或TNF-α刺激细胞后可产生CXCL5，嗜酸性细胞也可表达CXCL5，而II型干扰素IFN-γ可抑制其表达。CXCL5通过与细胞表面趋化因子受体CXCR2相互作用来发挥其作用效果，可刺激具有血管生成特性的中性粒细胞的趋化性，并参与结缔组织重塑。CXCL5同样具有调节中性粒细胞稳态的作用。CXCL5在动脉粥样硬化(一种慢性炎症状态)中表达较高，但与中性粒细胞的浸润无关。相反，CXCL5可直接控制巨噬细胞的泡沫细胞形成，从而对动脉粥样硬化起保护作用。

人 Human CXCL5 分子靶点信息

分子名：CXCL5, C-X-C motif chemokine ligand 5
别称：
- C-X-C motif chemokine 5
- chemokine (C-X-C motif) ligand 5
- ENA-78
- ENA-78(1-78)
- epithelial-derived neutrophil activating protein 78
- epithelial-derived neutrophil-activating peptide 78
- epithelial-derived neutrophil-activating protein 78
- neutrophil-activating peptide ENA-78
- neutrophil-activating protein 78
- SCYB5
- small inducible cytokine B5
- small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
- small-inducible cytokine B5
基因序列：NCBI_Gene: 6374
蛋白序列：UniProtKB: P42830

人 Human CXCL5靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in idiopathic pulmonary fibrosis. Biomarker of several diseases, including common cold; diffuse scleroderma; hyperhomocysteinemia; lung disease (multiple); and sinusitis.