EK1255A

Human IGFBP-1 ELISA Kit 检测试剂盒（酶联免疫吸附法）

Name: Human IGFBP-1 ELISA Kit 检测试剂盒（酶联免疫吸附法）
SKU: EK1255A
Availability: InStock

¥2,000.00 – ¥3,400.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

在售SKU:70-EK1255A-48, 70-EK1255A-96,EK1255A

分子靶点：IGFBP1
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：血清、血浆样本10μL
灵敏度：0.289pg/mL
检测范围：9.38-600pg/mL
回收率：82%-113%

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Size
库存号

ELISA试剂盒详细信息

商品名	Human IGFBP-1 ELISA Kit 检测试剂盒（酶联免疫吸附法）
种属	人
靶点	IGFBP1
检测方法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	血清、血浆样本10μL
灵敏度	0.289pg/mL
线性范围	9.38-600pg/mL
精密度	板内变异系数：2.7%-4.1%;板间变异系数：1.4%-3.2%
回收率	82%-113%
平均回收率
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IGFBP-1抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的IGFBP-1与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IGFBP-1的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

分子信息
IGFBP1 分子靶点信息概述
IGFBP1 分子靶点综述
- 人 Human IGFBP1 分子靶点信息
- 人 Human IGFBP1靶点分子功能（预测）

分子信息

概述人 IGFBP1, AFBP, IBP1 靶点信息

IGFBP1 分子靶点信息概述

分子名：IGFBP1, insulin like growth factor binding protein 1
基因家族：Insulin like growth factor binding proteins
别名：IGF-BP25; AFBP; hIGFBP-1; PP12
曾用名：IBP1
全称：placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associated endometrial globulin; growth hormone independent-binding protein; binding protein-28; binding protein-26; binding protein-25; IGF-binding protein 1; insulin-like growth factor binding protein 1

IGFBP1 分子靶点综述

胰岛素样生长因子-结合蛋白 1(IGFBP-1)也被称为胎盘蛋白 12(PP12)，是一种由 IGFBP1 基因编码的蛋白。它能结合胰岛素样生长因子(IGFs)I 和 II，并在血浆中循环。这样的结合延长了 IGFs 的半衰期，改变了它们与细胞表面受体的相互作用。IGFBPs 可以调节 IGF 蛋白的生物活性。IGFBP 的转录后修饰(如糖基化、磷酸化和蛋白水解)可改变结合蛋白与 IGF 的亲和力。高浓度 IGFBP-1 可能是分解代谢状态的标志，研究表明含高浓度 IGFBP-1 的女性具有较少的肌肉量。鼻咽癌患者血清中较高的 IGFBP-1/IGF-1 比与预后差显著相关。据报道，局部 IGFBP1 水平对冠状动脉斑块的形成有影响。

人 Human IGFBP1 分子靶点信息

分子名：IGFBP1, insulin like growth factor binding protein 1
别称：
- AFBP
- alpha-pregnancy-associated endometrial globulin
- amniotic fluid binding protein
- binding protein-25
- binding protein-26
- binding protein-28
- growth hormone independent-binding protein
- hIGFBP-1
- IBP-1
- IBP1
- IGF-binding protein 1
- IGF-BP25
- IGFBP-1
- insulin-like growth factor binding protein 1
- insulin-like growth factor-binding protein 1
- placental protein 12
- PP12
基因序列：NCBI_Gene: 3484
蛋白序列：UniProtKB: P08833

人 Human IGFBP1靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.