EK1138EG

EasyGo!™ Human TIMP-1 One-Step ELISA Kit检测试剂盒（酶联免疫吸附法）

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在售SKU:70-EK1138EG-48, 70-EK1138EG-96, EK1138EG

分子靶点：TIMP1
种属：人
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：100μL(100倍预稀释)
灵敏度：1.43pg/mL
检测范围：15.63-1000pg/mL
回收率：70%-130%

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ELISA试剂盒详细信息

商品名	EasyGo!™ Human TIMP-1 One-Step ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	TIMP1
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	100μL(100倍预稀释)
灵敏度	1.43pg/mL
线性范围	15.63-1000pg/mL
精密度	板内变异系数：< 10%;板间变异系数：< 10%
回收率	70%-130%
板式	96孔板，可拆
保存条件	2-8℃
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上，酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

文章目录[隐藏]

分子信息
TIMP1 分子靶点信息概述
TIMP1 分子靶点综述
- 人 Human TIMP1 分子靶点信息
- 人 Human TIMP1靶点分子功能（预测）

分子信息

概述人 TIMP1, TIMP-1, TIMP, EPO 靶点信息

TIMP1 分子靶点信息概述

分子名：TIMP1, TIMP metallopeptidase inhibitor 1
基因家族：Tissue inhibitor of metallopeptidases
别名：EPO
曾用名：TIMP; CLGI
全称：tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)

TIMP1 分子靶点综述

基质金属蛋白酶抑制剂-1(TIMP-1)是一种在生物体多种组织中表达的糖蛋白，是TIMP家族中的一员。TIMP-1是一种天然的基质金属蛋白酶(MMPs)抑制剂，后者是参与细胞外基质降解的一组肽酶。TIMP-1除了可抑制大多数已知的MMPs外，还可促进多种细胞类型的细胞繁殖，也可能具有抗凋亡作用。对许多细胞因子和激素的应答可强烈诱导该基因的转录。研究表明，人类女性中的TIMP-1基因失活是多态性的。肾上腺皮质细胞的营养激素ACTH诱导TIMP-1的表达，且TIMP表达的增加与胶原酶活性的降低有关。另外，TIMP-1表达的增加与多种肿瘤如喉癌或黑色素瘤的预后较差有关。

人 Human TIMP1 分子靶点信息

分子名：TIMP1, TIMP metallopeptidase inhibitor 1
别称：
- CLGI
- collagenase inhibitor
- EPA
- EPO
- erythroid potentiating activity
- erythroid-potentiating activity
- fibroblast collagenase inhibitor
- FLJ90373
- HCI
- metalloproteinase inhibitor 1
- TIMP
- TIMP-1
- tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
- tissue inhibitor of metalloproteinases 1
基因序列：NCBI_Gene: 7076
蛋白序列：UniProtKB: P01033

人 Human TIMP1靶点分子功能（预测）

Enables cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Involved in several processes, including cellular response to UV-A; negative regulation of proteolysis; and negative regulation of trophoblast cell migration. Located in extracellular space. Biomarker of several diseases, including CAKUT2; Down syndrome; artery disease (multiple); carcinoma (multiple); and diabetes mellitus (multiple).