EK187EG

EasyGo!™ Human CCL2 One-Step ELISA Kit检测试剂盒（酶联免疫吸附法）

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在售SKU:70-EK187EG-48, 70-EK187EG-96, EK187EG

分子靶点：CCL2
种属：人
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：20μL
灵敏度：0.36pg/mL
检测范围：3.91-250pg/mL
回收率：70%-130%

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ELISA试剂盒详细信息

商品名	EasyGo!™ Human CCL2 One-Step ELISA Kit检测试剂盒（酶联免疫吸附法）
种属	人
靶点	CCL2
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	20μL
灵敏度	0.36pg/mL
线性范围	3.91-250pg/mL
精密度	板内变异系数：< 10%;板间变异系数：< 10%
回收率	70%-130%
板式	96孔板，可拆
保存条件	2-8℃
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上，酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

文章目录[隐藏]

分子信息
CCL2 分子靶点信息概述
CCL2 分子靶点综述
- 人 Human CCL2 分子靶点信息
- 人 Human CCL2靶点分子功能（预测）

分子信息

概述人 CCL2, MCP-1, MCAF, SMC-CF 靶点信息

CCL2 分子靶点信息概述

分子名：CCL2, C-C motif chemokine ligand 2
基因家族：Chemokine ligands
别名：MCP1; MCP-1; MCAF; SMC-CF; GDCF-2; HC11; MGC9434
曾用名：SCYA2
全称：monocyte chemotactic protein 1, homologous to mouse Sig-je; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); chemokine (C-C motif) ligand 2

CCL2 分子靶点综述

趋化因子配体2(CCL2)，又名单核细胞趋化蛋白1(MCP-1)，是CC趋化因子家族的小分子量细胞因子。CCL2通过蛋白聚糖的粘多糖侧链锚定到内皮细胞的质膜上，主要由单核细胞、巨噬细胞和树突状细胞分泌。CCL2可招募单核细胞、记忆性T细胞和树突状细胞到组织损伤或感染引起的炎症位点。CCL2参与以单核细胞浸润为特征的一些疾病发病机制，如银屑病、类风湿性关节炎和动脉粥样硬化。CCL2参与发生在中枢神经系统的多种疾病的神经炎症过程，表现为神经元变性。

人 Human CCL2 分子靶点信息

分子名：CCL2, C-C motif chemokine ligand 2
别称：
- C-C motif chemokine 2
- chemokine (C-C motif) ligand 2
- GDCF-2
- HC11
- HSMCR30
- MCAF
- MCP-1
- MCP1
- MGC9434
- monocyte chemoattractant protein 1
- monocyte chemoattractant protein-1
- monocyte chemotactic and activating factor
- monocyte chemotactic protein 1
- monocyte secretory protein JE
- SCYA2
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
- small inducible cytokine subfamily A (Cys-Cys), member 2
- small-inducible cytokine A2
- SMC-CF
基因序列：NCBI_Gene: 6347
蛋白序列：UniProtKB: P13500

人 Human CCL2靶点分子功能（预测）

Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and regulation of apoptotic process. Located in extracellular region. Implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); liver disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and retinal disease (multiple).