EK2184EG

EasyGo!™ Mouse Progranulin/Granulin One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）

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在售SKU:70-EK2184EG-48, 70-EK2184EG-96, EK2184EG

分子靶点：GRN
种属：小鼠
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：100μL（6000倍预稀释）
灵敏度：6.90pg/mL
检测范围：39.063-2500pg/mL
回收率：70%-130%

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Size
库存号

ELISA试剂盒详细信息

商品名	EasyGo!™ Mouse Progranulin/Granulin One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）
种属	小鼠
靶点	GRN
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	100μL（6000倍预稀释）
灵敏度	6.90pg/mL
线性范围	39.063-2500pg/mL
精密度	板内变异系数：< 10%;板间变异系数：< 10%
回收率	70%-130%
板式	96孔板，可拆
保存条件	2-8℃
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上，酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

文章目录[隐藏]

分子信息
GRN 分子靶点信息概述
GRN 分子靶点综述
- 小鼠 Mouse Grn 分子靶点信息
- 小鼠 Mouse Grn 靶点分子功能（预测）

分子信息

概述小鼠 GRN, PGRN, granulin 靶点信息

GRN 分子靶点信息概述

分子名：GRN, granulin precursor
别名：PCDGF; PGRN; CLN11
全称：progranulin

GRN 分子靶点综述

颗粒体蛋白(GRN)在人类中由GRN基因编码。它的前体蛋白—颗粒蛋白前体，又名畸胎瘤细胞源性生长因子。信号肽被剪切后可产生成熟的GRN，进一步剪切可产生许多分子量为6kDa的活性多肽。肽和完整的GRN都可调节细胞生长。然而，GRN蛋白家族的不同成员可能对细胞生长产生抑制和/或促进作用。GRN家族成员对正常发育、伤口愈合和肿瘤发生有重要作用。GRN可能有细胞因子样活性，可在炎症、创伤修复和组织重塑中发挥作用。人肝吸虫可分泌类似GRN的生长激素，从而导致胆管癌的发展。GRN基因突变可通过高外显率的常染色体显性遗传，产生最高达25%的额颞叶变性。

小鼠 Mouse Grn 分子靶点信息

分子名：Grn, granulin
别称：
- acrogranulin
- epithelin
- PC cell-derived growth factor
- Pgrn
- progranulin
基因序列：NCBI_Gene: 14824
蛋白序列：

小鼠 Mouse Grn 靶点分子功能（预测）

Predicted to enable chaperone binding activity. Involved in several processes, including astrocyte activation involved in immune response; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and lysosomal protein catabolic process. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).