EK3391EG

EasyGo!™ Rat ACE2 One-Step ELISA Kit 检测试剂盒(酶联免疫吸附法)

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在售SKU:70-EK3391EG-48, 70-EK3391EG-96, EK3391EG

  • 分子靶点:ACE2
  • 种属:大鼠
  • 样本类型:血清,血浆,细胞培养上清及其他生物学样本
  • 检测样本体积:20μL
  • 灵敏度:0.029ng/mL
  • 检测范围:0.313-20ng/mL
  • 回收率:70%-130%
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ELISA试剂盒详细信息

商品名EasyGo!™ Rat ACE2 One-Step ELISA Kit 检测试剂盒(酶联免疫吸附法)
种属大鼠
靶点ACE2
检测方法双抗体夹心法
检测样本类型血清,血浆,细胞培养上清及其他生物学样本
检测样本体积20μL
灵敏度0.029ng/mL
线性范围0.313-20ng/mL
精密度板内变异系数:< 10%;板间变异系数:< 10%
回收率70%-130%
板式96孔板,可拆
保存条件2-8℃
运输条件2-8℃冰袋运输
检测原理本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上,酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后,加入显色底物(TMB),避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应,在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

分子信息

概述大鼠 Rat

ACE2 分子靶点信息概述

  • 分子名:ACE2, angiotensin converting enzyme 2
  • 别名:ACEH
  • 全称:peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2

ACE2 分子靶点综述

血管紧张素转换酶2(ACE-2),也称为ACEH(ACE同源物),是ACE家族不可或缺的膜蛋白和锌金属蛋白酶。ACE2是肾素-血管紧张素系统中调节血压的关键酶。ACE-2裂解血管紧张素I和II作为羧肽酶。具体而言,ACE2分别从血管紧张素I切割末端九肽或从血管紧张素II切割末端七肽以产生血管紧张素。产生的肽可抵抗血管紧张素II的作用,并起血管扩张剂的作用。ACE-2已被证明是人类冠状病毒SARS-CoV和SARS-CoV-2的功能性受体。

大鼠 Rat Ace2 分子靶点信息

大鼠 Rat Ace2 靶点分子功能(预测)

Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).

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