EK2170EG

EasyGo!™ Mouse EpCAM/CD326 One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）

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在售SKU:70-EK2170EG-48, 70-EK2170EG-96, EK2170EG

分子靶点：EPCAM
种属：小鼠
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：10μL
灵敏度：38.29pg/mL
检测范围：78.13-5000pg/mL
回收率：70%-130%

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ELISA试剂盒详细信息

商品名	EasyGo!™ Mouse EpCAM/CD326 One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）
种属	小鼠
靶点	EPCAM
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	10μL
灵敏度	38.29pg/mL
线性范围	78.13-5000pg/mL
精密度	板内变异系数：< 10%;板间变异系数：< 10%
回收率	70%-130%
板式	96孔板，可拆
保存条件	2-8℃
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上，酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

文章目录[隐藏]

分子信息
EPCAM 分子靶点信息概述
EPCAM 分子靶点综述
- 小鼠 Mouse Epcam 分子靶点信息
- 小鼠 Mouse Epcam 靶点分子功能（预测）

分子信息

概述小鼠 EPCAM, CD326 靶点信息

EPCAM 分子靶点信息概述

分子名：EPCAM, epithelial cell adhesion molecule
基因家族：CD molecules; MicroRNA protein coding host genes
别名：Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; MOC-31; 323/A3; 17-1A; TACST-1; CO-17A; ESA; BerEp4; Ber-Ep4
曾用名：M4S1; MIC18; TACSTD1
全称：antigen identified by monoclonal antibody AUA1; tumor-associated calcium signal transducer 1; trophoblast cell surface antigen 1

EPCAM 分子靶点综述

上皮细胞黏附分子（EpCAM），又称CD326、GA733-2抗原等，是一种I型跨膜糖蛋白。其结构包含：具有两个EGF样重复序列和半胱氨酸富集区的胞外域、跨膜域以及胞质域。该分子不仅调控细胞黏附和增殖，其过表达现象已在多种上皮源性肿瘤中被发现，并与某些肿瘤的高分期、高级别及不良预后显著相关。
研究表明，EpCAM作为一种钙离子非依赖性的同嗜性细胞黏附分子，其作用机制与已知的四大细胞黏附分子超家族均无明确关联。研究进展揭示，EpCAM除参与细胞黏附外，还在细胞增殖、迁移及分化过程中发挥重要作用。值得注意的是，近期研究发现EpCAM可作为Wnt/β-catenin信号通路的靶基因，具有潜在的预后评估价值。
该分子具有致癌潜能：当其胞内结构域被释放后，可通过激活Wnt信号通路的关键元件向细胞核转导信号。这一机制为理解EpCAM在肿瘤发生发展中的作用提供了新的分子基础。

小鼠 Mouse Epcam 分子靶点信息

分子名：Epcam, epithelial cell adhesion molecule
别称：
- CD326
- EGP-2
- Egp314
- Ep-CAM
- EpCAM
- EpCAM1
- epithelial glycoprotein 314
- GA733-2
- gp40
- Ly74
- lymphocyte antigen 74
- panepithelial glycoprotein 314
- Tacstd1
- TROP1
- tumor-associated calcium signal transducer 1
基因序列：NCBI_Gene: 17075
蛋白序列：

小鼠 Mouse Epcam 靶点分子功能（预测）

Predicted to enable cadherin binding activity involved in cell-cell adhesion. Involved in ureteric bud development. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diarrhea 5 with tufting enteropathy. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule).