EK2153EG

EasyGo!™ Mouse IL6RA One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）

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在售SKU:70-EK2153EG-48, 70-EK2153EG-96, EK2153EG

分子靶点：IL6R
种属：小鼠
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：100μL（100倍预稀释）
灵敏度：0.34pg/mL
检测范围：6.25-400pg/mL
回收率：70%-130%

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Size
库存号

ELISA试剂盒详细信息

商品名	EasyGo!™ Mouse IL6RA One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）
种属	小鼠
靶点	IL6R
检测方法	双抗体夹心法
检测样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	100μL（100倍预稀释）
灵敏度	0.34pg/mL
线性范围	6.25-400pg/mL
精密度	板内变异系数：< 10%;板间变异系数：< 10%
回收率	70%-130%
板式	96孔板，可拆
保存条件	2-8℃
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上，酶标板孔中预先加入辣根过氧化物酶标记的检测抗体微球。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入显色底物（TMB），避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在450nm波长 (参考波长570 - 630nm) 测定吸光度值。

文章目录[隐藏]

分子信息
IL6R 分子靶点信息概述
IL6R 分子靶点综述
- 小鼠 Mouse Il6ra 分子靶点信息
- 小鼠 Mouse Il6ra 靶点分子功能（预测）

分子信息

概述小鼠 IL6R, IL-6R, IL-1Ra, CD126 靶点信息

IL6R 分子靶点信息概述

分子名：IL6R, interleukin 6 receptor
基因家族：CD molecules; Immunoglobulin like domain containing; Interleukin receptors
别名：CD126; IL-6R; IL-1Ra; IL6RA; gp80
全称：membrane glycoprotein 80; interleukin 6 receptor subunit alpha

IL6R 分子靶点综述

白细胞介素 6 受体是由 IL-6 受体亚基(IL-6Rα)和信号转导糖蛋白 130(gp130)组成的复合物。可溶性IL-6Rα的分子量约 50kDa，由膜 IL-6Rα经蛋白水解产生。该受体可在溶液中与 IL-6 结合，使 IL-6/IL-6sRα复合物与膜gp130 结合，增强IL-6 活性。目前调控体内可溶性 IL-6R 的脱落以及这些受体的功能和重要性尚未知。然而涉及 IL-6 水平升高的病理状态也许与可溶性 IL-6R 含量升高有关。

小鼠 Mouse Il6ra 分子靶点信息

分子名：Il6ra, interleukin 6 receptor, alpha
别称：
- CD126
- IL-6 receptor alpha chain
- IL-6R
- Il6r
- interleukin 6 receptor
基因序列：NCBI_Gene: 16194
蛋白序列：

小鼠 Mouse Il6ra 靶点分子功能（预测）

Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).